Reflection of18 F-FDG accumulation in the evaluation of the extent of periapical or periodontal inflammation

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology Vol. 114; no. 6; pp. e62 - e69
• Main Authors: Kito, Shinji, DDS, PhD, Koga, Hirofumi, MD, PhD, Kodama, Masaaki, DDS, PhD, Yamamoto, Noriaki, DDS, PhD, Kokuryo, Shinya, DDS, PhD, Habu, Manabu, DDS, PhD, Matsuo, Kou, DDS, PhD, Nishino, Takanobu, DDS, PhD, Kubota, Kohzoh, DDS, PhD, Muraoka, Kosuke, DDS, PhD, Oda, Masafumi, DDS, Wakasugi-Sato, Nao, DDS, PhD, Matsumoto-Takeda, Shinobu, DDS, PhD, Seta, Yuji, DDS, PhD, Tanaka, Tatsurou, DDS, PhD, Miyamoto, Ikuya, DDS, PhD, Yamashita, Yoshihiro, DDS, PhD, Kitamura, Chiaki, DDS, PhD, Nakashima, Keisuke, DDS, PhD, Takahashi, Tetsu, DDS, PhD, Tominaga, Kazuhiro, DDS, PhD, Morimoto, Yasuhiro, DDS, PhD
• Format: Journal Article
• Language: English
• Published: 2012
• Subjects: Surgery
• DOI: 10.1016/j.oooo.2012.05.027
• ISSN: 2212-4403

Objectives To elucidate whether fluorine-18-labeled (18 F) fluoro-2-deoxy- d -glucose (FDG) accumulation can reflect the extent of periodontal inflammation, periapical inflammation, or dental caries. Study Design18 F-FDG accumulations on positron emission tomography (PET)-computed tomography (CT) were retrospectively compared with the size of the bone resorption areas caused by periodontal inflammation, periapical inflammation, or dental caries on panoramic radiographs, CT, and magnetic resonance imaging (MRI) in 44 subjects. Results A significant correlation was found between the size of the bone resorption area caused by periodontal ( r = 0.595, P < .01) or periapical ( r = 0.560, P < .01) inflammation and the highest standardized uptake value (SUVmax) of18 F-FDG accumulation. A significant correlation was found between the periodontal ( r = 0.622, P < .01) or periapical ( r = 0.394, P < .01) inflammatory findings on MRI and the SUVmax of18 F-FDG accumulation. The SUVmax of18 F-FDG around most teeth with caries was under 1.5. Conclusions18 F-FDG accumulation reflects the extent of dental inflammation, not dental caries.