The Asian atopic dermatitis phenotype combines features of atopic dermatitis and psoriasis with increased TH 17 polarization

• Published in: Journal of allergy and clinical immunology Vol. 136; no. 5; pp. 1254 - 1264
• Main Authors: Noda, Shinji, MD, PhD, Suárez-Fariñas, Mayte, PhD, Ungar, Benjamin, BA, Kim, Soo Jung, MD, PhD, de Guzman Strong, Cristina, PhD, Xu, Hui, MSc, Peng, Xiangyu, MSc, Estrada, Yeriel D., BSc, Nakajima, Saeko, MD, PhD, Honda, Tetsuya, MD, PhD, Shin, Jung U., MD, Lee, Hemin, MD, Krueger, James G., MD, PhD, Lee, Kwang-Hoon, MD, PhD, Kabashima, Kenji, MD, PhD, Guttman-Yassky, Emma, MD, PhD
• Format: Journal Article
• Language: English
• Published: 2015
• Subjects: Allergy and Immunology; FLG; Immunohistochemistry; IHC; Filaggrin; T H17; Asian; T H2; T H1; T H22; European American; Real-time PCR; Atopic dermatitis; RT-PCR; parakeratosis; EA; Fold change; Dendritic cell; AD; STAT1; Signal transducer and activator of transcription 1; FCH; PCA; Langerhans cell; psoriasis; LC; acanthosis; DC; Principal component analysis

Background Atopic dermatitis (AD) shows very high prevalence in Asia, with a large unmet need for effective therapeutics. Direct comparisons between European American (EA) and Asian patients with AD are unavailable, but earlier blood studies detected increased IL-17+ –producing cell counts in Asian...