Neural differentiation of glioblastoma cell lines via a herpes simplex virus thymidine kinase/ganciclovir system driven by a glial fibrillary acidic protein promoter

• Published in: PloS one Vol. 16; no. 8
• Main Authors: Elizabeth Wei-Chia Luo, Meng-Lin Liao, Chung-Liang Chien
• Format: Journal Article
• Language: English
• Published: Public Library of Science (PLoS) 01.01.2021

Glioblastoma is a malignant brain tumor with poor prognosis that rapidly acquires resistance to available clinical treatments. The herpes simplex virus thymidine kinase/ganciclovir (HSVtk/GCV) system produces the selective elimination of HSVtk-positive cells and is a candidate for preclinical testin...