Association of Diabetes and Metformin Use with Gastric Cancer: A Case-Control Study
Background and purpose: Recently, several studies have shown type 2 diabetes to be associated with gastric cancer and metformin appears to inhibit the growth of cancer cells by inducing apoptosis. This study was conducted to investigate the relationship between metformin and gastric cancer. Material...
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Published in | Majallah-i dānishgāh-i ulū m-i pizishkī Māzandarān Vol. 32; no. 217; pp. 105 - 112 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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Mazandaran University of Medical Sciences
01.01.2023
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Abstract | Background and purpose: Recently, several studies have shown type 2 diabetes to be associated with gastric cancer and metformin appears to inhibit the growth of cancer cells by inducing apoptosis. This study was conducted to investigate the relationship between metformin and gastric cancer. Materials and methods: This case-control study included patients with gastric cancer (case group, n= 121) and a family member of patients with cancer (control group, n= 119). Diabetes history, duration and management of glucose level were recorded in a checklist and data were analyzed in SPSS applying T-test and Chi-square test. Also, logistic regression was used to calculate the odds ratio. Results: There were significant differences between the case group and control group in terms of age, gender, place of residence, level of education, BMI, and smoking (P<0.05). The adjusted odds ratio for history of diabetes was 0.87 (Adjusted OR=0.87, CI95%: 0.3-2.35) which was not significant (P=0.751). The study showed no significant difference between the two groups in history of diabetes control drugs (including metformin) (P>0.05). Conclusion: According to current study, it appears that, in north of Iran, there is no association between gastric cancer and diabetes, control drugs (including metformin), and other factors such as duration of diabetes or a family history of diabetes. |
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AbstractList | Background and purpose: Recently, several studies have shown type 2 diabetes to be associated with gastric cancer and metformin appears to inhibit the growth of cancer cells by inducing apoptosis. This study was conducted to investigate the relationship between metformin and gastric cancer. Materials and methods: This case-control study included patients with gastric cancer (case group, n= 121) and a family member of patients with cancer (control group, n= 119). Diabetes history, duration and management of glucose level were recorded in a checklist and data were analyzed in SPSS applying T-test and Chi-square test. Also, logistic regression was used to calculate the odds ratio. Results: There were significant differences between the case group and control group in terms of age, gender, place of residence, level of education, BMI, and smoking (P<0.05). The adjusted odds ratio for history of diabetes was 0.87 (Adjusted OR=0.87, CI95%: 0.3-2.35) which was not significant (P=0.751). The study showed no significant difference between the two groups in history of diabetes control drugs (including metformin) (P>0.05). Conclusion: According to current study, it appears that, in north of Iran, there is no association between gastric cancer and diabetes, control drugs (including metformin), and other factors such as duration of diabetes or a family history of diabetes. |
Author | Mahtab Rameshgar Adeleh Bahar Akbar Hedayatizadeh-Omran Reyhaneh Shojaei-Asrami Reza Alizadeh-Navaei Mohammad Eslami Jouibari |
Author_xml | – sequence: 1 fullname: Mahtab Rameshgar organization: Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran – sequence: 2 fullname: Adeleh Bahar organization: Professor, Department of Internal Medicine, Diabetes Research Center, Sari Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran – sequence: 3 fullname: Mohammad Eslami Jouibari organization: Assistant Professor, Department of Internal Medicine, Sari Imam Khomeini Hospital, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran – sequence: 4 fullname: Akbar Hedayatizadeh-Omran organization: Associate Professor, Gastrointestinal Cancer Research Center, Non-communicable Diseases Research Institutes, Mazandaran University of Medical Sciences, Sari, Iran – sequence: 5 fullname: Reyhaneh Shojaei-Asrami organization: Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran – sequence: 6 fullname: Reza Alizadeh-Navaei organization: Associate Professor, Gastrointestinal Cancer Research Center, Non-communicable Diseases Research Institutes, Mazandaran University of Medical Sciences, Sari, Iran |
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Snippet | Background and purpose: Recently, several studies have shown type 2 diabetes to be associated with gastric cancer and metformin appears to inhibit the growth... |
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SubjectTerms | diabetes gastric cancer metformin |
Title | Association of Diabetes and Metformin Use with Gastric Cancer: A Case-Control Study |
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