Research progress of DNA damage repair and its effect on perioperative cognitive dysfunction

• Published in: Ji chu yi xue yu lin chuang = Jichu yixue yu linchuang = Basic medical sciences and clinics Vol. 42; no. 4; pp. 675 - 678
• Main Author: RONG Yu-lan, SHI Cheng-mei, GUO Xiang-yang
• Format: Journal Article
• Language: Chinese
• Published: Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College 01.04.2022
• Subjects: dna damage repair|non-homologous end joining|perioperative cognitive dysfunction
• DOI: 10.16352/j.issn.1001-6325.2022.04.009
• ISSN: 1001-6325

The dynamic balance between DNA double-strand break (DSB) accumulation and repair is one of the important factors to maintain genomic stability. The homologous recombination (HR) and the non-homologous ending joining (NHEJ) are the two major pathways to repair DSB.In mature neurons of the central nervous system, the NHEJ is the main repair pathway of DSB.Recent studies in the molecular mechanism of NHEJ and peri-operative cognitive dysfunction (POCD) revealed several molecular mechanisms underlying the DNA damage repair and its links to POCD, which may provide a new therapeutic target.