Differential depletion of GluN2A induces heterogeneous schizophrenia-related phenotypes in miceResearch in context

• Published in: EBioMedicine Vol. 102; p. 105045
• Main Authors: Yi Lu, Longyu Mu, Justin Elstrott, Chaoying Fu, Cailu Sun, Tonghui Su, Xiaofan Ma, Jia Yan, Hong Jiang, Jesse E. Hanson, Yang Geng, Yelin Chen
• Format: Journal Article
• Language: English
• Published: Elsevier 01.04.2024
• Subjects: Conditional knockout mouse; Excitatory synaptic transmission; GluN2A; Medial prefrontal cortex; NMDA receptor; Schizophrenia

Background: Schizophrenia, a debilitating psychiatric disorder, displays considerable interindividual variation in clinical presentations. The ongoing debate revolves around whether this heterogeneity signifies a continuum of severity linked to a singular causative factor or a collection of distinct...