IMMUNITY IN PATIENTS WITH TROPHOBLASTIC DISEASE

• Published in: Opukholi zhenskoĭ reproduktivnoĭ sistemy no. 1-2; pp. 63 - 67
• Main Authors: B. O. Toloknov, E. G. Slavina, Z. G. Kadagidze, K. P. Laktionov, Е. Е. Makhova, A. I. Chertkova, I. V. Markina
• Format: Journal Article
• Language: Russian
• Published: ABV-press 01.09.2014
• Subjects: chemotherapy; hydatidiform mole; immunity; suppressor cells; trophoblastic disease
• DOI: 10.17650/1994-4098-2009-0-1-2-63-67
• ISSN: 1994-4098

The investigation included 39 female patients with different forms of trophoblastic disease whose immunity was studied by the cur- rently available procedures. The patients were divided into 2 groups. Group 1 comprised 29 patients with a history of hydatidiform mole, who received no chemotherapy (CT) since an analysis of the data did not show the presence of a trophoblastic tumor. Group 2 consisted of 10 patients with a verified trophoblastic tumor who received CT with various drugs. The patients with trophoblastic disease were found to have some abnormal immunological parameters; however, they differ little in patients with the malignant and benign course of the disease and cannot serve as a prognostic factor. Activated lymphocytes were substantially increased in both groups, suggesting an active immune response to antigen-foreign cells expressing along with parenteral antigens. The patients with hydatidiform mole have the sign to be further studied, that is a reduction in the count of СD25-positive Т lymphocytes, pos- sibly, suppressor cells.