Gut-innervating TRPV1+ Neurons Drive Chronic Visceral Pain via Microglial P2Y12 ReceptorSummary

• Published in: Cellular and molecular gastroenterology and hepatology Vol. 13; no. 4; pp. 977 - 999
• Main Authors: Manon Defaye, Nasser S. Abdullah, Mircea Iftinca, Ahmed Hassan, Francina Agosti, Zizhen Zhang, Melissa Cumenal, Gerald W. Zamponi, Christophe Altier
• Format: Journal Article
• Language: English
• Published: Elsevier 01.01.2022
• Subjects: Microglia; P2RY12; TRPV1 Neurons; Visceral Pain

Background & Aims: Chronic abdominal pain is a common symptom of inflammatory bowel diseases (IBDs). Peripheral and central mechanisms contribute to the transition from acute to chronic pain during active disease and clinical remission. Lower mechanical threshold and hyperexcitability of viscera...