Expression of Functional Recombinant Human Coagulation Factor VII Protein in Mammalian Cells

• Published in: Majallah-i dānishkadah-i pizishkī-i Iṣfahān. (Online) Vol. 1; no. 1; pp. 1145 - 1150
• Main Authors: Amir Mashayekhi, Shirin Shahbazi, Mirdavood Omrani
• Format: Journal Article
• Language: Persian
• Published: Isfahan University of Medical Sciences 01.11.2017
• Subjects: Cloning; Coagulation factor VII; HepG2 cells; Recombinant proteins

Background: Coagulation factor 7 (FVII) is a vitamin-k-dependent serine protease with an essential role in initiation of extrinsic pathway of coagulation cascade. Extrinsic pathway is the major mechanism of clot formation in physiologic conditions. Congenital deficiency of FVII is a recessively inhe...