Tofacitinib-Induced Modulation of Intestinal Adaptive and Innate Immunity and Factors Driving Cellular and Systemic PharmacokineticsSummary

• Published in: Cellular and molecular gastroenterology and hepatology Vol. 13; no. 2; pp. 383 - 404
• Main Authors: Bernhard Texler, Andreas Zollner, Vera Reinstadler, Simon J. Reider, Sophie Macheiner, Barbara Jelusic, Alexandra Pfister, Christina Watschinger, Nicole Przysiecki, Herbert Tilg, Herbert Oberacher, Alexander R. Moschen
• Format: Journal Article
• Language: English
• Published: Elsevier 01.01.2022
• Subjects: inflammatory bowel disease; JAK inhibitor; mucosal inflammation; pharmacokinetics; tofacitinib

Objective: By interfering with multiple cytokines, human Janus kinase inhibitors (JAKis) are of growing importance in the treatment of malignant and inflammatory conditions. Although tofacitinib has demonstrated efficacy as the first-in-class JAKi in ulcerative colitis many aspects concerning its mo...