Telocytes in the Luminal GI TractSummary
Telocytes are unique mesenchymal cells characterized by multiple remarkably long cytoplasmic extensions that extend hundreds of micron away from the cell body. Through these extensions, telocytes establish a 3-dimensional network by connecting with other telocytes and various cell types within the t...
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| Published in | Cellular and molecular gastroenterology and hepatology Vol. 17; no. 5; pp. 697 - 701 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier
01.01.2024
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Telocytes are unique mesenchymal cells characterized by multiple remarkably long cytoplasmic extensions that extend hundreds of micron away from the cell body. Through these extensions, telocytes establish a 3-dimensional network by connecting with other telocytes and various cell types within the tissue. In the intestine, telocytes have emerged as an essential component of the stem cell niche, providing Wnt proteins that are critical for the proliferation of stem and progenitor cells. However, the analysis of single-cell RNA sequencing has revealed other stromal populations and mechanisms for niche organization, raising questions about the role of telocytes as a component of the stem cell niche. This review explores the current state-of-the-art, existing controversies, and potential future directions related to telocytes in the luminal gastrointestinal tract. |
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| AbstractList | Telocytes are unique mesenchymal cells characterized by multiple remarkably long cytoplasmic extensions that extend hundreds of micron away from the cell body. Through these extensions, telocytes establish a 3-dimensional network by connecting with other telocytes and various cell types within the tissue. In the intestine, telocytes have emerged as an essential component of the stem cell niche, providing Wnt proteins that are critical for the proliferation of stem and progenitor cells. However, the analysis of single-cell RNA sequencing has revealed other stromal populations and mechanisms for niche organization, raising questions about the role of telocytes as a component of the stem cell niche. This review explores the current state-of-the-art, existing controversies, and potential future directions related to telocytes in the luminal gastrointestinal tract. |
| Author | Michal Shoshkes-Carmel |
| Author_xml | – sequence: 1 fullname: Michal Shoshkes-Carmel organization: Correspondence Address correspondence to: Michal Shoshkes-Carmel, PhD, Institute for Medical Research Israel-Canada, Hebrew University Medical School, Jerusalem, Israel.; Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hebrew University Medical School, Jerusalem, Israel |
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| Snippet | Telocytes are unique mesenchymal cells characterized by multiple remarkably long cytoplasmic extensions that extend hundreds of micron away from the cell body.... |
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| SubjectTerms | Intestinal homeostasis Stem-cell niche Stroma |
| Title | Telocytes in the Luminal GI TractSummary |
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