Advances in Multiomic Analyses of Frailty Biomarkers in the Elderly

Early diagnosis of frailty is of great value in helping the elderly to regain their health, as it is a non-specific state of reduced physiological reserve, resistance to disease and ability to recover from stress caused by the impairment in homeostasis maintained by multiple systems with sarcopenia...

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Published inZhongguo quanke yixue Vol. 26; no. 23; pp. 2871 - 2876
Main Author XU Ting, JI Minghui, CHEN Yimeng, GAO Yu, ZHU Hanfei, DING Lingyu, XU Qin
Format Journal Article
LanguageChinese
Published Chinese General Practice Publishing House Co., Ltd 01.08.2023
Subjects
frailty|pre-frailty|aged|multi-omics|biomarkers|review
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Abstract Early diagnosis of frailty is of great value in helping the elderly to regain their health, as it is a non-specific state of reduced physiological reserve, resistance to disease and ability to recover from stress caused by the impairment in homeostasis maintained by multiple systems with sarcopenia as the basic characteristic. Recent developments in multiomic techniques provide new approaches to the detection of potentially specific, stable and reliable biomarkers of pre-frailty. We collected and reviewed recent advances in multiomic techniques for identifying frailty biomarkers, involving genomics, transcriptomics, proteomics and metabolomics, which can assist in assessing the risk of frailty, exploring potential mechanisms of frailty and developing targeted interventions to support healthy aging.
AbstractList Early diagnosis of frailty is of great value in helping the elderly to regain their health, as it is a non-specific state of reduced physiological reserve, resistance to disease and ability to recover from stress caused by the impairment in homeostasis maintained by multiple systems with sarcopenia as the basic characteristic. Recent developments in multiomic techniques provide new approaches to the detection of potentially specific, stable and reliable biomarkers of pre-frailty. We collected and reviewed recent advances in multiomic techniques for identifying frailty biomarkers, involving genomics, transcriptomics, proteomics and metabolomics, which can assist in assessing the risk of frailty, exploring potential mechanisms of frailty and developing targeted interventions to support healthy aging.
Author XU Ting, JI Minghui, CHEN Yimeng, GAO Yu, ZHU Hanfei, DING Lingyu, XU Qin
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Snippet Early diagnosis of frailty is of great value in helping the elderly to regain their health, as it is a non-specific state of reduced physiological reserve,...
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SubjectTerms frailty|pre-frailty|aged|multi-omics|biomarkers|review
Title Advances in Multiomic Analyses of Frailty Biomarkers in the Elderly
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