Ciclooxigenasa 3: the new iso-enzime

In 2002, Simmons etal from the Brigham Young University identifi ed a new form ofcyclooxygenase, which was called cyclooxygenase-3. This,basically, derives from the cyclooxygenase-1 gene codifi erbut it differs structurally and functionally from COX-1. It hasbeen established that PGs COX-3 produces...

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Bibliographic Details
Published inMedUNAB Vol. 7; no. 21; pp. 181 - 184
Main Author Oscar Enrique Pradilla Vesga
Format Journal Article
LanguageSpanish
Published Universidad Autonoma de Bucaramanga 01.12.2004
Subjects
Acetaminophen
COX-3
Cyclooxygenase
Cylooxygenase-3
Fever
Pain
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Summary:In 2002, Simmons etal from the Brigham Young University identifi ed a new form ofcyclooxygenase, which was called cyclooxygenase-3. This,basically, derives from the cyclooxygenase-1 gene codifi erbut it differs structurally and functionally from COX-1. It hasbeen established that PGs COX-3 produces fever and centralpain but not infl ammation. When pharmacological inhibitionfrom several drugs were tested, acetaminophen was identified as the most selective inhibitor. Following this discovery,af ter 60 years fi nally the pharmacological mechanism for the acetaminophen was clarifi ed.
ISSN:0123-7047