Purificação e caracterização da beta-lapachona e estudo de estabilidade dos cristais em diferentes condições de armazenamento Purification and characterization of beta-lapachone and stability study of the crystals under different storing conditions

• Published in: Química nova Vol. 31; no. 2; pp. 413 - 416
• Main Authors: Geisiane Maria Cavalcante Alves, Larissa Araújo Rolim, Pedro José Rolim Neto, Ana Cristina Lima Leite, Dalci José Brondani, Flávia Patrícia Morais de Medeiros, Lothar W. Bieber, Francisco Jaime Bezerra Mendonça Junior
• Format: Journal Article
• Language: English
• Published: Sociedade Brasileira de Química 01.01.2008
• Subjects: beta-lapachone; characterization and stability study
• DOI: 10.1590/S0100-40422008000200039
• ISSN: 0100-4042

The beta-lapachone is a product obtained from the Ipê Roxo tree [Tabebuia avellandae], which has proved its excellent antineoplasic potential acting through a particular mechanism of apoptosis against various cancer types. This study aims at determining the identity card of beta-lapachone by means of physico-chemical and pharmaco-technical characterization. A purifying process has been performed, as well as the isolation of a contaminant, its isomer alpha-lapachone. A stability study was also performed, determining the ideal storing conditions for beta-lapachone, essential for the ongoing pre-formulation studies for obtaining the different classic pharmaceutical forms and modified release systems.