Factors Influencing Biochemical Progression in Distant Metastatic Papillary Thyroid Carcinoma

• Published in: Zhongguo quanke yixue Vol. 27; no. 36; pp. 4546 - 4553
• Main Author: ZHANG Jin, SUN Di, WANG Hao, SHI Cong, ZHAO Yihan, PAN Yijin, MU Zhuanzhuan, DING Zhiguo, LIN Yansong
• Format: Journal Article
• Language: Chinese
• Published: Chinese General Practice Publishing House Co., Ltd 01.12.2024
• Subjects: papillary thyroid carcinoma|distant metastasis|biochemical progression|thyroglobulin doubling time|t lymphocyte subsets|gene mutation
• DOI: 10.12114/j.issn.1007-9572.2023.0930
• ISSN: 1007-9572

Background In advanced papillary thyroid carcinoma (PTC), particularly distant metastatic PTC (DM-PTC), disease progression is primarily monitored through serum markers like thyroglobulin (Tg) and imaging modalities such as computed tomography (CT). Due to limitations inherent in imaging techniques, such as radiation exposure, high cost, and complexity of metastatic lesion distribution, Response Evaluation Criteria In Solid Tumors version 1.1 (RECIST 1.1) often fail to timely capture disease changes in DM-PTC patients. The integration of Tg doubling time (TgDT) has demonstrated its efficacy in sensitively monitoring PTC disease progression. Objective To explore the biochemical progression and its influencing factors in DM-PTC using TgDT as the outcome variable. Methods This retrospective study included 61 DM-PTC patients treated at the Department of Nuclear Medicine, Peking Union Medical College Hospital from January 2018 to June 2023. Baseline data and genetic mutation analyses (including BRAF mutation, TERT