沉默信息调节蛋白1在缺血性脑损伤中的神经保护作用 The Neuroprotective Effect of Silent Information Regulator Protein 1 in Ischemic Brain Injury

• Published in: Zhongguo cuzhong zazhi Vol. 13; no. 1; pp. 86 - 89
• Main Author: 李传文，汪青松
• Format: Journal Article
• Language: Chinese
• Published: Editorial Department of Chinese Journal of Stroke 01.01.2018
• Subjects: deacetylase; neuroprotection; silent information regulator protein 1 (sirt1); 去乙酰化酶; 沉默信息调节蛋白1; 神经保护
• ISSN: 1673-5765
• DOI: 10.3969/j.issn.1673-5765.2018.01.020

近年来，沉默信息调节蛋白1（silent information regulator protein 1，SIRT1）作为依赖NAD+ 的组蛋白去乙酰化酶被广泛地研究。SIRT1存在于机体各组织细胞中，通过去乙酰化修饰，调节细胞 的多种生理过程，在能量守恒、细胞氧化、衰老及凋亡等方面发挥重要作用。目前认为，SIRT1在缺血 性脑损伤中起到神经保护作用，可能通过调控细胞能量代谢，抗炎性反应、抗细胞凋亡等方面发挥 作用。本文主要综述了SIRT1在缺血性脑损伤中的神经保护作用。 Abstract: In recent years, silent information regulator 1 (SIRT1) has been widely studied as a nicotinamide adenine dinucleotide-dependent deacetylase, which exists in various tissues and cells of the body. SIRT1 regulates many cellular physiological processes through the acetylation modification. It plays an important role in energy conservation, cell oxidation, aging and apoptosis, etc. Now, it is believed that SIRT1 plays a vital role of neuroprotection effects in the ischemic brain injury through regulating cell energy metabolism, anti-inflammatory reaction and anti-apoptosis, etc. This paper mainly reviews the research progress on neuroprotection effects of SIRT1 in the ischemic brain injury.