Gastrin treatment stimulates beta cell regeneration and improves glucose tolerance in 95% pancreatectomized rats

• Published in: Endocrinology (Philadelphia)
• Main Authors: Téllez i Besolí, Noèlia, Joanny Ordóñez, Géraldine, Escoriza, Jessica, Vilaseca Barceló, Marina, Montanya Mias, Eduard
• Format: Journal Article
• Language: English
• Published: Association for the Study of Internal Secretions 01.07.2011
• Subjects: B cells; Cèl·lules B; Gastrin; Gastrina; Glucosa; Glucose; Therapeutic use; Toleration; Tolerància; Ús terapèutic

β-Cell mass reduction is a central aspect in the development of type 1 and type 2 diabetes, and substitution or regeneration of the lost β-cells is a potentially curative treatment of diabetes. To study the effects of gastrin on β-cell mass in rats with 95% pancreatectomy (95%-Px), a model of pancre...