Single nucleotide polymorphisms in the Wnt and BMP pathways and colorectal cancer risk in a Spanish population

• Published in: PloS one
• Main Authors: Fernández-Rozadilla, Ceres, Castro, Luisa de, Clofent, Juan, Brea-Fernández, Alejandro, Bessa i Caserras, Xavier, Abulí, Anna, Andreu, Montserrat, Jover, Rodrigo, Xicola, Rosa, Llor, Xavier, Castells Garangou, Antoni, Castellví-Bel, Sergi, Carracedo Álvarez, Ángel, Ruiz-Ponte, Clara, Gastrointestinal Oncology Group of the Spanish Gas
• Format: Journal Article
• Language: English
• Published: Public Library of Science (PLoS) 09.09.2010
• Subjects: Colorectal cancer; Càncer colorectal; Epidemiologia genètica; Espanya; Genetic epidemiology; Genètica humana; Human genetics; Spain

Background Colorectal cancer (CRC) is considered a complex disease, and thus the majority of the genetic susceptibility is thought to lie in the form of low-penetrance variants following a polygenic model of inheritance. Candidate-gene studies have so far been one of the basic approaches taken to id...