SARS-CoV-2 Interaction with Human DNA Methyl Transferase 1: A Potential Risk for Increasing the Incidence of Later Chronic Diseases in the Survived Patients
Currently, the COVID-19 pandemic is the most discussed subject in medical researches worldwide. As the knowledge is expanded about the disease, more hypotheses become created. A recent study on the viral protein interaction map revealed that SARS-CoV-2 open reading frame 8 (ORF8) interacts with huma...
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| Published in | International journal of preventive medicine Vol. 13; no. 1 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
01.01.2022
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| Online Access | Get full text |
| ISSN | 2008-7802 2008-8213 |
| DOI | 10.4103/ijpvm.IJPVM_628_20 |
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| Abstract | Currently, the COVID-19 pandemic is the most discussed subject in medical researches worldwide. As the knowledge is expanded about the disease, more hypotheses become created. A recent study on the viral protein interaction map revealed that SARS-CoV-2 open reading frame 8 (ORF8) interacts with human DNA methyl transferase1 (DNMT1), an active epigenetic agent in DNA methylation. Moreover, DNMT1 is a contributor to a variety of chronic diseases which could cause some epigenetic dysregulation in infected cells, especially leukocytes, pancreatic beta, and endothelial cells. Regarding the fact that epigenetic alterations have a partial, but not completely reversible phenomena, it raises the question that if this interaction may cause long-term complications such as diabetes, atherosclerosis, cancer, and autoimmune diseases. Accordingly, long follow-up studies on the recovered patients from COVID-19 are recommended. |
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| AbstractList | Currently, the COVID-19 pandemic is the most discussed subject in medical researches worldwide. As the knowledge is expanded about the disease, more hypotheses become created. A recent study on the viral protein interaction map revealed that SARS-CoV-2 open reading frame 8 (ORF8) interacts with human DNA methyl transferase1 (DNMT1), an active epigenetic agent in DNA methylation. Moreover, DNMT1 is a contributor to a variety of chronic diseases which could cause some epigenetic dysregulation in infected cells, especially leukocytes, pancreatic beta, and endothelial cells. Regarding the fact that epigenetic alterations have a partial, but not completely reversible phenomena, it raises the question that if this interaction may cause long-term complications such as diabetes, atherosclerosis, cancer, and autoimmune diseases. Accordingly, long follow-up studies on the recovered patients from COVID-19 are recommended. |
| Author | Fakhrolmobasheri, Mohammad Zeinalian, Mehrdad Shiravi, Amirabbas |
| Author_xml | – sequence: 1 givenname: Mohammad surname: Fakhrolmobasheri fullname: Fakhrolmobasheri, Mohammad organization: Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran – sequence: 2 givenname: Amirabbas surname: Shiravi fullname: Shiravi, Amirabbas organization: Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran – sequence: 3 givenname: Mehrdad surname: Zeinalian fullname: Zeinalian, Mehrdad organization: Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran, Pediatric Inherited Diseases Research Center, Research Institute for Primordial Prevention of Non-Communicable Diseases, Isfahan University of Medical Sciences, Isfahan, Iran, Iranians Cancer Control Charity Institute (MACSA), Isfahan, Iran |
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| References | Wu (R16-20250813) 2017; 7 Hervouet (R3-20250813) 2010; 1 Chakravarthy (R8-20250813) 2017; 25 Chen (R9-20250813) 2016; 7 Hou (R6-20250813) 2018; 191 Jiang (R5-20250813) 2019; 224 Sunahori (R10-20250813) 2013; 288 Zaina (R4-20250813) 2014; 25 Zhou (R12-20250813) 2014; 7 Chen (R7-20250813) 2015; 6 Yu (R11-20250813) 2016; 6 Eckstein (R15-20250813) 2017; 331 Gordon (R2-20250813) 2020; 583 Hervouet (R13-20250813) 2010; 5 Zhou (R14-20250813) 2018; 18 Wu (R17-20250813) 2020 |
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