Alloantigen-specific Chimeric Antigen Receptor Regulatory T cell therapy in non-human primate islet transplantation

• Published in: The Journal of immunology (1950) Vol. 208; no. 1_Supplement; pp. 175 - 175.21
• Main Authors: Ellis, Gavin I., Coker, Kimberly E., Winn, Delaine W., Deng, Mosha Z., Shukla, Divanshu, Bhoj, Vijay, Milone, Michael C., Wang, Wei, Liu, Chengyang, Naji, Ali, Duran-Struuck, Raimon, Riley, James L.
• Format: Journal Article
• Language: English
• Published: 01.05.2022

Abstract Though islet transplantation has emerged as a promising therapeutic for type 1 diabetes, the immunosuppressive agents that prevent rejection carry significant risk of morbidity. Adoptive transfer of chimeric antigen receptor (CAR) Tregs has the potential to protect allografts and transform...