Receptor interacting protein kinase 1 (RIPK1) pathways regulate innate B cell developmental checkpoints and delay effector function

• Published in: The Journal of immunology (1950) Vol. 206; no. 1_Supplement; pp. 98 - 98.12
• Main Authors: Parthasarathy, Raksha, Hagglof, Thomas, McLennan, Alexandra, Mattke, Aiden, Dudley, Elizabeth, Kumagai, Abigail, Leadbetter, Elizabeth A
• Format: Journal Article
• Language: English
• Published: 01.05.2021

Mutations in RIP kinases underlie the recently described human autoimmune syndrome, CRIA, characterized by lymphadenopathy, splenomegaly, and autoantibody production. While disease mechanisms for CRIA remain undescribed, RIP kinases work together with Caspase-8 to regulate cell death, which is criti...