Lin28b promotes innate functions in CD8+ T cells through rapid chromatin remodeling

• Published in: The Journal of immunology (1950) Vol. 206; no. 1_Supplement; pp. 24 - 24.12
• Main Authors: Watson, Neva B, Patel, Ravi K, Oyesola, Oyebola O, Laniewski, Nathan, Smith, Norah L, Mon, Kristel Yee, Tabilas, Cybelle, Daly, Ciaran, West, Jessica D, Luyen, Vu Tien, Maymi, Viviana I, Nzingha, Kito, Wesnak, Samantha P, Scheible, Kristin M, Wojno, Elia D Tait, Grimson, Andrew W, Rudd, Brian D
• Format: Journal Article
• Language: English
• Published: 01.05.2021

Abstract Lin28b serves as a master regulator of fetal lymphopoiesis and promotes the development of more innate-like lymphocytes in early life. However, it is still unclear how Lin28b alters the function of CD8+ T cells and protects the host against infection. In this report we examined how Lin28b t...