Sphingosine Kinase Inhibitors Effectively Inhibit Growth of Mast Cells with D816V-KIT Mutations

Sphingosine-1-phosphate (S1P) is a lipid mediator that promotes cell proliferation and prevents apoptosis in a variety of cells and its increased synthesis by Sphingosine Kinase (SphK) has been associated with oncogenesis and cancer prognosis. Mastocytosis is a disorder characterized by excessive ma...

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Bibliographic Details
Published inThe Journal of immunology (1950) Vol. 198; no. 1_Supplement; pp. 145 - 145.13
Main Authors AGEITOS, ARACELI TOBIO, BANDARA, GEETHANI, MUNOZ-CANO, ROSA, YIN, YUZHI, DESAI, AVANTI, METCALFE, DEAN, OLIVERA, ANA
Format Journal Article
LanguageEnglish
Published 01.05.2017
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