Combined blockade of IL-4R and IKKβ inhibits melanoma growth in vivo (P2032)

• Published in: The Journal of immunology (1950) Vol. 190; no. 1_Supplement; pp. 132 - 132.6
• Main Authors: Hawkins, Oriana, Horton, Linda, Martin, Tyesha, Ayers, Gregory, Richmond, Ann
• Format: Journal Article
• Language: English
• Published: 01.05.2013

Abstract Constitutive activation of the nuclear factor kappa B (NF-κB) is common in melanoma, promoting tumor growth and metastasis. Therefore, targeting the NF-κB pathway is a possible therapeutic option. However, NF- κB activity is critical for the development and function of immune cells. Melanom...