Human tumor-infiltrating Th17 cells have the capacity to differentiate into IFN-gamma+ and FOXP3+ T cells with potent suppressive function (66.27)

• Published in: The Journal of immunology (1950) Vol. 186; no. 1_Supplement; pp. 66 - 66.27
• Main Authors: Peng, Guangyong, Ye, Jian, Su, Xinming, Hsueh, Eddy, Zhang, Yanping, Koenig, Joyce, Hoft, Daniel
• Format: Journal Article
• Language: English
• Published: 01.04.2011

Abstract Accumulating evidence suggests that T-helper 17 (Th17) cells and regulatory T (Treg) cells may exhibit development plasticity, and that CD4+ Tregs can differentiate into IL-17-producing T cells; however, whether Th17 cells can reciprocally convert into Tregs has not been described. In this...