An activating mutation in CD45 generates a novel murine model of hemophagocytic disorders in the context of a MHC Class 1 restricted TCR. (109.11)

• Published in: The Journal of immunology (1950) Vol. 186; no. 1_Supplement; pp. 109 - 109.11
• Main Authors: Tibbetts, Rachelle, Lam, Viola, Cresalia, Nicole, DeGraaf, Fleur, Goren, Nira, Wong, Lawrence, Hai, Si-Han, Mills, Robyn, Roque, Alfonso, Arthur, Weiss, Hermiston, Michelle
• Format: Journal Article
• Language: English
• Published: 01.04.2011

Abstract Hemophagocytic syndromes encompass a spectrum of life-threatening disorders characterized by severe systemic inflammation and mechanistically are not well understood. We inadvertently generated a novel mouse model that shares many characteristics of these hyperinflammatory conditions. Expre...