An activating mutation in CD45 generates a novel murine model of hemophagocytic disorders in the context of a MHC Class 1 restricted TCR. (109.11)
Abstract Hemophagocytic syndromes encompass a spectrum of life-threatening disorders characterized by severe systemic inflammation and mechanistically are not well understood. We inadvertently generated a novel mouse model that shares many characteristics of these hyperinflammatory conditions. Expre...
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Published in | The Journal of immunology (1950) Vol. 186; no. 1_Supplement; pp. 109 - 109.11 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
01.04.2011
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Online Access | Get full text |
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