Investigating mechanisms for limited CD8 T-cell expansion in experimental visceral leishmaniasis. (40.5)

• Published in: The Journal of immunology (1950) Vol. 184; no. 1_Supplement; pp. 40 - 40.5
• Main Authors: Bankoti, Rashmi, Stager, Simona
• Format: Journal Article
• Language: English
• Published: 01.04.2010

Abstract Leishmania donovani, a causative agent of visceral leishmaniasis, establishes chronic infections in the spleen in humans and in mice. Thus far, the only cells that are known to be able to reduce the splenic parasite burden following immunotherapy in mice are antigen-specific CD8+ T-cells. Y...