Orthobiologics for knee osteoarthritis: A review of current practice and future directions
Knee osteoarthritis (OA) represents a significant challenge in modern orthopedics due to its prevalence and debilitating impact on patients’ quality of life. Traditional treatment options such as analgesics, physical therapy, and corticosteroid injections have shown varying degrees of efficacy in ma...
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| Published in | Journal of Arthroscopic Surgery and Sports Medicine Vol. 5; pp. 119 - 124 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
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24.08.2024
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| Abstract | Knee osteoarthritis (OA) represents a significant challenge in modern orthopedics due to its prevalence and debilitating impact on patients’ quality of life. Traditional treatment options such as analgesics, physical therapy, and corticosteroid injections have shown varying degrees of efficacy in managing symptoms and controlling disease progression. Of late, there has been a growing interest in orthobiologics as a potential therapeutic approach for knee OA. The existing literature on orthobiologics was searched using the keywords “Orthobiologics,” “Knee,” and “Osteoarthritis”. The term orthobiologics encompasses a wide range of biological substances, including platelet-rich plasma (PRP), Bone Marrow aspiration concentrate (BMAC), Autologous conditioned serum (ACS), mesenchymal stem cells (MSCs), and gene therapeutics which are believed to promote tissue repair and regeneration. This review aims to discuss and compare the existing orthobiologics (for knee OA) and the scope of research to develop better formulations possessing enhanced disease modifying effects in the future. Despite the growing enthusiasm, challenges such as standardization of preparation protocols, optimal dosage, and patient selection criteria remain. Moreover, the long-term effects of orthobiologics on joint structure and function require further investigation. |
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| AbstractList | Knee osteoarthritis (OA) represents a significant challenge in modern orthopedics due to its prevalence and debilitating impact on patients’ quality of life. Traditional treatment options such as analgesics, physical therapy, and corticosteroid injections have shown varying degrees of efficacy in managing symptoms and controlling disease progression. Of late, there has been a growing interest in orthobiologics as a potential therapeutic approach for knee OA. The existing literature on orthobiologics was searched using the keywords “Orthobiologics,” “Knee,” and “Osteoarthritis”. The term orthobiologics encompasses a wide range of biological substances, including platelet-rich plasma (PRP), Bone Marrow aspiration concentrate (BMAC), Autologous conditioned serum (ACS), mesenchymal stem cells (MSCs), and gene therapeutics which are believed to promote tissue repair and regeneration. This review aims to discuss and compare the existing orthobiologics (for knee OA) and the scope of research to develop better formulations possessing enhanced disease modifying effects in the future. Despite the growing enthusiasm, challenges such as standardization of preparation protocols, optimal dosage, and patient selection criteria remain. Moreover, the long-term effects of orthobiologics on joint structure and function require further investigation. |
| ArticleNumber | 119 |
| Author | Thami, Tarkik Patel, Sandeep Kumar, Prasoon Gupta, Ansh |
| Author_xml | – sequence: 1 givenname: Tarkik surname: Thami fullname: Thami, Tarkik organization: Department of Orthopaedics, Postgraduate Institute of Medical Education and Research, Chandigarh, India – sequence: 2 givenname: Prasoon surname: Kumar fullname: Kumar, Prasoon organization: Department of Orthopaedics, Postgraduate Institute of Medical Education and Research, Chandigarh, India – sequence: 3 givenname: Ansh surname: Gupta fullname: Gupta, Ansh organization: Department of Orthopaedics, Postgraduate Institute of Medical Education and Research, Chandigarh, India – sequence: 4 givenname: Sandeep surname: Patel fullname: Patel, Sandeep organization: Department of Orthopaedics, Postgraduate Institute of Medical Education and Research, Chandigarh, India |
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| Cites_doi | 10.1093/pcmedi/pbad014 10.3109/14653249.2011.629645 10.1007/s43465-024-01145-z 10.2106/JBJS.21.01112 10.1177/23259671241227863 10.1007/s00011-003-1197-1 10.1097/BOR.0000000000000918 10.1177/2325967115625481 10.1186/s13075-017-1363-4 10.1007/s00167-011-1837-x 10.2217/rme-2017-0152 10.1002/art.1780400604 10.1016/j.joca.2008.03.017 10.2460/ajvr.68.3.290 10.1182/blood.V78.1.55.55 10.1002/art.38576 10.1177/1947603510392023 10.1007/s40610-020-00142-z 10.3389/fimmu.2024.1362012 10.3390/ijms24010059 10.1002/jgm.3002 10.1007/s00590-013-1393-9 10.1016/j.joca.2008.06.014 10.1007/s43465-024-01159-7 10.1016/j.knee.2010.03.001 10.1007/s00402-024-05310-9 10.1016/j.pain.2011.08.001 10.1177/0363546516662455 10.1038/s41598-021-83025-2 10.1038/nprot.2010.81 10.1016/j.cellsig.2018.10.005 10.1177/0363546512471299 10.1002/art.27492 10.1007/s00167-018-5118-9 10.1016/j.eats.2016.10.024 10.1177/2325967120S00454 10.4103/jmsr.jmsr_64_20 |
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