Hepatic Overexpression of Retinoic Acid Receptor ß Downregulates Mitochondrial Pyruvate Carrier 1 and Protects from Metabolic Dysregulation in ob/ob Mice

• Published in: Diabetes (New York, N.Y.) Vol. 67; no. Supplement_1
• Main Authors: KEYHANI NEJAD, FARNAZ, LEE, DONGHWAN, CHEN, HANQING, LIANG, ZERONG, MUSI, NICOLAS, ZANG, MENGWEI
• Format: Journal Article
• Language: English
• Published: 01.07.2018

Our recent studies identify that retinoic acid receptor β (RARβ), a vitamin A-related nuclear receptor, regulates mitochondrial fatty acid oxidation in hepatocytes and in vivo in a fasting-inducible manner, which contributes to the metabolic adaptation to fasting. Mitochondrial pyruvate carrier (MPC...