POLYMERIC MATERIALS AS PLATFORMS FOR TOPICAL DRUG DELIVERY: A REVIEW

With the emergence of novel and more effective drug therapies, increased importance is being placed upon the drug delivery technology. Topical formulations are attractive alternatives to oral formulations and offer several advantages, such as avoiding first-pass hepatic metabolism and gastric degrad...

Full description

Saved in:
Bibliographic Details
Published inInternational journal of pharmacy and pharmaceutical sciences pp. 14 - 20
Main Authors Teo, Siew Yong, Lee, Siang Yin, Rathbone, Michael J., Gan, Seng Neon
Format Journal Article
LanguageEnglish
Published 01.01.2017
Online AccessGet full text

Cover

Abstract With the emergence of novel and more effective drug therapies, increased importance is being placed upon the drug delivery technology. Topical formulations are attractive alternatives to oral formulations and offer several advantages, such as avoiding first-pass hepatic metabolism and gastric degradation. The major obstacle to drug delivery across the skin (transdermal) is the barrier nature of the skin which limits permeation of molecules. A wide range of polymeric materials is currently available for drug delivery to and across the skin. The synthetic polymers such as polyesters, polyamides, polyurethanes, polyanhydrides and poly(ortho-esters) display advantages of reproducibility of synthesis, a range of material properties and biodegradability, whereas agro-polymers like polysaccharides, proteins and lipids have already shown great promise in terms of type of material, range of properties, processing technique and biocompatibility. This review article summarizes features of different polymers and their potential applications in topical drug delivery system.
AbstractList With the emergence of novel and more effective drug therapies, increased importance is being placed upon the drug delivery technology. Topical formulations are attractive alternatives to oral formulations and offer several advantages, such as avoiding first-pass hepatic metabolism and gastric degradation. The major obstacle to drug delivery across the skin (transdermal) is the barrier nature of the skin which limits permeation of molecules. A wide range of polymeric materials is currently available for drug delivery to and across the skin. The synthetic polymers such as polyesters, polyamides, polyurethanes, polyanhydrides and poly(ortho-esters) display advantages of reproducibility of synthesis, a range of material properties and biodegradability, whereas agro-polymers like polysaccharides, proteins and lipids have already shown great promise in terms of type of material, range of properties, processing technique and biocompatibility. This review article summarizes features of different polymers and their potential applications in topical drug delivery system.
Author Lee, Siang Yin
Gan, Seng Neon
Teo, Siew Yong
Rathbone, Michael J.
Author_xml – sequence: 1
  givenname: Siew Yong
  surname: Teo
  fullname: Teo, Siew Yong
– sequence: 2
  givenname: Siang Yin
  surname: Lee
  fullname: Lee, Siang Yin
– sequence: 3
  givenname: Michael J.
  surname: Rathbone
  fullname: Rathbone, Michael J.
– sequence: 4
  givenname: Seng Neon
  surname: Gan
  fullname: Gan, Seng Neon
BookMark eNqdjtFqg0AQRYeQQGybTwjMD2hn1mgwb4tuWmFFWU1KnpZQDBjaRFwo9O8r0v5A78M9cOHCeYD57X5rAdZMgRAcJc_dte9dIIi3X0nHAYchxTPwKNlGPm8SnoMn4ij2aVyWsHLuSmM2JJhCD7Kq1KdCmTzFQjYjpa5R1lhp2exLU9Q4NjZlladSY2YOL5gpnR-VOe1QolHHXL09weJy_nDt6pePEO1Vk77678PduaG92H7oPs_Dt2Wyk7WdrO2ftZ2sw__-fgD7LUnn
Cites_doi 10.35652/IGJPS.2012.47
10.3109/10837450.2012.712537
10.1295/polymj.3.113
10.1155/2010/652719
10.1128/MMBR.63.1.21-53.1999
10.1016/j.jconrel.2004.12.021
10.3390/molecules20022816
10.1177/0883911514521919
10.1016/S0169-409X(02)00055-8
10.1016/S1389-1723(03)80059-2
10.3390/ijms15033640
10.4172/2157-7463.1000143
10.1002/ppap.201300149
10.1007/s10924-013-0633-8
10.1016/j.biomaterials.2004.10.002
10.1007/s10118-014-1420-2
10.1295/polymj.28.256
10.1016/S0079-6700(97)00039-7
10.4236/jbise.2009.24038
10.4103/2348-0734.131784
10.2147/IJN.S45821
10.15376/biores.7.2.2506-2552
10.1002/9780470649848.ch9
10.1295/polymj.14.643
10.1155/2013/916571
10.1016/j.progpolymsci.2007.05.017
10.3390/polym3031377
10.1007/978-3-642-03287-5_14
10.1177/155892501400900309
10.1016/j.colsurfb.2011.02.005
10.1155/2014/801820
10.1089/jop.2009.0074
10.1163/016942410X500954
10.1002/polb.22259
10.1089/ten.1995.1.241
10.1155/2012/270383
10.5301/JABB.2011.8867
10.1128/AEM.65.4.1703-1709.1999
10.1155/2013/409572
10.1155/2013/417672
10.1016/j.jconrel.2004.08.006
10.3390/polym3041972
10.1590/S0366-69132012000400011
10.1208/s12249-011-9661-7
10.1295/polymj.34.659
10.1002/wnan.1211
10.1016/S0142-9612(00)00107-1
10.1007/s13233-012-0072-8
10.1111/j.1750-3841.2007.00301.x
10.1007/978-3-642-38649-7_5
10.1016/j.ijpharm.2010.07.052
10.1016/S0964-8305(02)00051-3
10.1002/app.32887
10.1590/S0104-66322008000200011
10.4312/dp.41.11
10.1002/1097-4636(200102)54:2<162::AID-JBM2>3.0.CO;2-3
10.1016/j.foodchem.2006.07.016
10.1007/s10856-014-5169-5
10.1021/bm501652d
10.5772/23927
10.5772/56220
10.1016/j.ejpb.2011.09.004
10.1155/2013/567908
10.1016/S0378-5173(01)00811-0
10.1111/j.1472-765X.2008.02323.x
10.1016/j.progpolymsci.2011.07.003
10.1016/j.compositesa.2005.04.015
ContentType Journal Article
DBID AAYXX
CITATION
DOI 10.22159/ijpps.2017v9i1.13306
DatabaseName CrossRef
DatabaseTitle CrossRef
DatabaseTitleList CrossRef
DeliveryMethod fulltext_linktorsrc
Discipline Pharmacy, Therapeutics, & Pharmacology
EISSN 0975-1491
EndPage 20
ExternalDocumentID 10_22159_ijpps_2017v9i1_13306
GroupedDBID ---
2WC
53G
5VS
AAYXX
ADBBV
ALMA_UNASSIGNED_HOLDINGS
BAWUL
CITATION
DIK
GX1
HH5
KQ8
M~E
OK1
P6G
RNS
TR2
ID FETCH-crossref_primary_10_22159_ijpps_2017v9i1_133063
ISSN 2656-0097
IngestDate Fri Aug 23 00:44:26 EDT 2024
IsPeerReviewed false
IsScholarly true
Language English
LinkModel OpenURL
MergedId FETCHMERGED-crossref_primary_10_22159_ijpps_2017v9i1_133063
ParticipantIDs crossref_primary_10_22159_ijpps_2017v9i1_13306
PublicationCentury 2000
PublicationDate 2017-01-01
PublicationDateYYYYMMDD 2017-01-01
PublicationDate_xml – month: 01
  year: 2017
  text: 2017-01-01
  day: 01
PublicationDecade 2010
PublicationTitle International journal of pharmacy and pharmaceutical sciences
PublicationYear 2017
References 293977
293976
293979
293978
293973
293972
293975
293974
293971
293970
293988
293987
293989
293984
293983
293986
293985
293980
293982
293981
293908
293907
293909
293904
293906
293905
293911
293999
293910
293998
293913
293912
293995
293994
293997
293996
293991
293990
293993
293992
293919
293918
293915
293914
293917
293916
293922
293921
293924
293923
293920
293929
293926
293925
293928
293927
293933
293932
293935
293934
293931
293930
293937
293936
293939
293938
293944
293943
293946
293945
293940
293942
293941
293948
293947
293949
293955
293954
293957
293956
293951
293950
294005
293953
293952
294002
294001
294004
294003
294000
293959
293958
293966
293965
293968
293967
293962
293961
293964
293963
293960
293969
References_xml – ident: 293909
  doi: 10.35652/IGJPS.2012.47
– ident: 293958
  doi: 10.3109/10837450.2012.712537
– ident: 293906
– ident: 293979
  doi: 10.1295/polymj.3.113
– ident: 293941
– ident: 293922
  doi: 10.1155/2010/652719
– ident: 293959
  doi: 10.1128/MMBR.63.1.21-53.1999
– ident: 293986
  doi: 10.1016/j.jconrel.2004.12.021
– ident: 293915
– ident: 293952
  doi: 10.3390/molecules20022816
– ident: 293933
  doi: 10.1177/0883911514521919
– ident: 293938
– ident: 293955
– ident: 293989
  doi: 10.1016/S0169-409X(02)00055-8
– ident: 293947
– ident: 293965
  doi: 10.1016/S1389-1723(03)80059-2
– ident: 293961
– ident: 293945
  doi: 10.3390/ijms15033640
– ident: 293996
– ident: 293929
  doi: 10.4172/2157-7463.1000143
– ident: 293975
– ident: 293912
– ident: 293956
  doi: 10.1002/ppap.201300149
– ident: 293932
  doi: 10.1007/s10924-013-0633-8
– ident: 293934
  doi: 10.1016/j.biomaterials.2004.10.002
– ident: 293969
  doi: 10.1007/s10118-014-1420-2
– ident: 293972
  doi: 10.1295/polymj.28.256
– ident: 293904
– ident: 293910
– ident: 294001
– ident: 293983
  doi: 10.1016/S0079-6700(97)00039-7
– ident: 293980
  doi: 10.4236/jbise.2009.24038
– ident: 293924
  doi: 10.4103/2348-0734.131784
– ident: 293951
  doi: 10.2147/IJN.S45821
– ident: 293991
  doi: 10.15376/biores.7.2.2506-2552
– ident: 293999
– ident: 293913
– ident: 293907
– ident: 293926
  doi: 10.1002/9780470649848.ch9
– ident: 293921
  doi: 10.1295/polymj.14.643
– ident: 293982
  doi: 10.1155/2013/916571
– ident: 293988
  doi: 10.1016/j.progpolymsci.2007.05.017
– ident: 293994
– ident: 293939
  doi: 10.3390/polym3031377
– ident: 293968
  doi: 10.1007/978-3-642-03287-5_14
– ident: 293954
  doi: 10.1177/155892501400900309
– ident: 293970
  doi: 10.1016/j.colsurfb.2011.02.005
– ident: 293925
  doi: 10.1016/j.progpolymsci.2007.05.017
– ident: 294000
  doi: 10.1155/2014/801820
– ident: 293946
  doi: 10.1089/jop.2009.0074
– ident: 293977
– ident: 293978
  doi: 10.1163/016942410X500954
– ident: 293931
– ident: 293935
  doi: 10.1002/polb.22259
– ident: 293937
  doi: 10.1089/ten.1995.1.241
– ident: 294003
  doi: 10.1155/2012/270383
– ident: 293960
– ident: 293923
  doi: 10.5301/JABB.2011.8867
– ident: 293919
– ident: 293964
  doi: 10.1128/AEM.65.4.1703-1709.1999
– ident: 293927
  doi: 10.1155/2013/409572
– ident: 293993
  doi: 10.1155/2013/417672
– ident: 293984
  doi: 10.1016/j.jconrel.2004.08.006
– ident: 293917
  doi: 10.3390/polym3041972
– ident: 293957
  doi: 10.1590/S0366-69132012000400011
– ident: 293905
– ident: 293948
  doi: 10.1208/s12249-011-9661-7
– ident: 293962
  doi: 10.1295/polymj.34.659
– ident: 293940
– ident: 294004
  doi: 10.1002/wnan.1211
– ident: 293985
  doi: 10.1016/S0142-9612(00)00107-1
– ident: 293992
– ident: 293916
– ident: 293942
  doi: 10.1007/s13233-012-0072-8
– ident: 293908
– ident: 293971
  doi: 10.1111/j.1750-3841.2007.00301.x
– ident: 293990
  doi: 10.1007/978-3-642-38649-7_5
– ident: 294005
– ident: 293950
  doi: 10.1016/j.ijpharm.2010.07.052
– ident: 293974
  doi: 10.1016/S0964-8305(02)00051-3
– ident: 293967
  doi: 10.1002/app.32887
– ident: 293920
– ident: 293918
  doi: 10.1590/S0104-66322008000200011
– ident: 293998
  doi: 10.4312/dp.41.11
– ident: 293936
  doi: 10.1002/1097-4636(200102)54:2<162::AID-JBM2>3.0.CO;2-3
– ident: 293976
– ident: 293995
  doi: 10.1016/j.foodchem.2006.07.016
– ident: 293953
– ident: 293966
  doi: 10.1007/s10856-014-5169-5
– ident: 293973
  doi: 10.1021/bm501652d
– ident: 293911
– ident: 293943
  doi: 10.5772/23927
– ident: 293987
  doi: 10.5772/56220
– ident: 294002
– ident: 293928
– ident: 293944
  doi: 10.1016/j.ejpb.2011.09.004
– ident: 293981
  doi: 10.1155/2013/567908
– ident: 293949
  doi: 10.1016/S0378-5173(01)00811-0
– ident: 293963
  doi: 10.1111/j.1472-765X.2008.02323.x
– ident: 293997
  doi: 10.1016/j.progpolymsci.2011.07.003
– ident: 293914
– ident: 293930
  doi: 10.1016/j.compositesa.2005.04.015
SSID ssj0000402103
ssib044741383
Score 4.058303
Snippet With the emergence of novel and more effective drug therapies, increased importance is being placed upon the drug delivery technology. Topical formulations are...
SourceID crossref
SourceType Aggregation Database
StartPage 14
Title POLYMERIC MATERIALS AS PLATFORMS FOR TOPICAL DRUG DELIVERY: A REVIEW
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3LTsJQEL1B3LgxPuM7d2HYlFb6otRdI8gjBRpaDawaCsXAAomCiX6Fn-zcR28bJUbc3ECTTlrmZObMZOaA0DWwVHUynpRkY6xDgaLZqjwcjWLZrpTLVqzHUPuQBed2p9x4MFp9s5_LfWamllbLSBl9rN0r-Y9X4Rr4lWzJbuBZYRQuwGfwL5zgYTj_5GOv6w7ovzZKbQdoadNxfcnxJc91AijuoESHUwq6HtU8qPYe6lK15jYfa70BW0jPjEbM0on2tEGYkZVYMIlrptbEvySNcJ5FBTsPWP_Vn1JJKJ4a06EfHxD5JA2m6Q4asNDombVW-Ri_1FLEZBBv0cZwUyfmKOJ9CtXK9CloONOAOcpkbYRlHt6EtEwZajQ1E0LZTilPxnRR7keY14CnEJnU6WyxIJLrqvVmT1UFyu3SGlntb-lODCFC-UMNhdRMmJgJqZkttK1B6CJDgvW-iICGAQRM54SM5nqD1MxkjEG8HlsTo5Zv1j1ghgBlmEywh3Z5CYIdhqd9lIvnB6jgcQcXcZCu5L0WcQF7qbr5-yGqCtBhATrs-FiADsOJOegwAR1OQHeLHcwgd4TM-1pw15CTZwwXTPUk_PXn0o9Rfg5AOUHYjjTdnljaMCpHhhFrQ8u0KzbQciCWpaGqnyJlM9tnm95wjnZSAF6g_PJlFV8CdVxGV9SbX6UUY30
link.rule.ids 315,783,787,27938,27939
linkProvider Geneva Foundation for Medical Education and Research
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=POLYMERIC+MATERIALS+AS+PLATFORMS+FOR+TOPICAL+DRUG+DELIVERY%3A+A+REVIEW&rft.jtitle=International+journal+of+pharmacy+and+pharmaceutical+sciences&rft.au=Teo%2C+Siew+Yong&rft.au=Lee%2C+Siang+Yin&rft.au=Rathbone%2C+Michael+J.&rft.au=Gan%2C+Seng+Neon&rft.date=2017-01-01&rft.issn=2656-0097&rft.eissn=0975-1491&rft.spage=14&rft.epage=20&rft_id=info:doi/10.22159%2Fijpps.2017v9i1.13306&rft.externalDBID=n%2Fa&rft.externalDocID=10_22159_ijpps_2017v9i1_13306
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2656-0097&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2656-0097&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2656-0097&client=summon