Preliminary safety evaluation of n-butanol from the collagen extraction process and of collagen extract from Oreochromis niloticus (tilapia) skin oriented for dermocosmetics Avaliação preliminar da segurança do n-butanol do processo de extração de colágeno e do extrato de colágeno da pele de Oreochromis niloticus (tilápia) para uso dermocosmético
Obtaining new cosmetic ingredients, mainly from sustainable sources, as novel excipients or even active compounds is noteworthy for the cosmetic industry to enhance new innovative dermocosmetics. Thus, it is essential to establish the safety of these new ingredients to avoid adverse events, mainly t...
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Published in | Jornal de investigação biomédica e biofarmacêutica (Em linha) Vol. 18; no. 1; p. 123 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
2021
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Abstract | Obtaining new cosmetic ingredients, mainly from sustainable sources, as novel excipients or even active compounds is noteworthy for the cosmetic industry to enhance new innovative dermocosmetics. Thus, it is essential to establish the safety of these new ingredients to avoid adverse events, mainly those associated with clastogenic effects from the chemical compounds used for collagen extraction. In this study, we evaluated solutions of chemical compounds used in the collagen extraction process from tilapia skin (Oreochromis niloticus). The cytotoxic and genotoxic effects of the solutions used in the collagen extraction process were 10.0, 1.0, 0.5, and 0.1% n-butanol. Solutions were evaluated by the Allium test and the comet assay in peripheral white blood cells. The residual water from the final skin wash in the pre-treatment phase and the 0.5% lyophilized collagen extract were also investigated. The absence of cytotoxic and genotoxic activity was demonstrated in the collagen extract, despite the fact that n-butanol showed DNA damage, both in the root cells of Allium cepa and in the white blood cells of human peripheral blood. Therefore, we note the necessity to carry out genotoxicity tests to guarantee the absence of contaminants in the collagen extract for cosmetic purposes |
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AbstractList | Obtaining new cosmetic ingredients, mainly from sustainable sources, as novel excipients or even active compounds is noteworthy for the cosmetic industry to enhance new innovative dermocosmetics. Thus, it is essential to establish the safety of these new ingredients to avoid adverse events, mainly those associated with clastogenic effects from the chemical compounds used for collagen extraction. In this study, we evaluated solutions of chemical compounds used in the collagen extraction process from tilapia skin (Oreochromis niloticus). The cytotoxic and genotoxic effects of the solutions used in the collagen extraction process were 10.0, 1.0, 0.5, and 0.1% n-butanol. Solutions were evaluated by the Allium test and the comet assay in peripheral white blood cells. The residual water from the final skin wash in the pre-treatment phase and the 0.5% lyophilized collagen extract were also investigated. The absence of cytotoxic and genotoxic activity was demonstrated in the collagen extract, despite the fact that n-butanol showed DNA damage, both in the root cells of Allium cepa and in the white blood cells of human peripheral blood. Therefore, we note the necessity to carry out genotoxicity tests to guarantee the absence of contaminants in the collagen extract for cosmetic purposes |
Author | Ayala-Jara, Carmen Daud Sarruf, Fernanda Salirrosas, David Reátegui-Pinedo, Nataly Rolim Baby, André Sánchez-Tuest, Linda Quevedo-León, Roberto Fiestas, Ramiro Adriana Prieto, Zulita Morocho-Jácome, Ana Lucía Miliani Martinez, Renata |
Author_xml | – sequence: 1 givenname: Linda surname: Sánchez-Tuest fullname: Sánchez-Tuest, Linda organization: Universidad Nacional de Trujillo, Trujillo, Perú – sequence: 2 givenname: Nataly surname: Reátegui-Pinedo fullname: Reátegui-Pinedo, Nataly organization: Universidad Nacional de Trujillo, Trujillo, Perú – sequence: 3 givenname: David surname: Salirrosas fullname: Salirrosas, David organization: Universidad Nacional de Trujillo, Trujillo, Perú – sequence: 4 givenname: Ana Lucía surname: Morocho-Jácome fullname: Morocho-Jácome, Ana Lucía organization: Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Braz – sequence: 5 givenname: Fernanda surname: Daud Sarruf fullname: Daud Sarruf, Fernanda organization: Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Braz – sequence: 6 givenname: Renata surname: Miliani Martinez fullname: Miliani Martinez, Renata organization: Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Braz – sequence: 7 givenname: Roberto surname: Quevedo-León fullname: Quevedo-León, Roberto organization: Universidad de Los Lagos, Osorno, Chile – sequence: 8 givenname: Ramiro surname: Fiestas fullname: Fiestas, Ramiro organization: Universidad Nacional de Trujillo, Trujillo, Perú – sequence: 9 givenname: Carmen surname: Ayala-Jara fullname: Ayala-Jara, Carmen organization: Universidad Nacional de Trujillo, Trujillo, Perú – sequence: 10 givenname: André surname: Rolim Baby fullname: Rolim Baby, André organization: Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Braz – sequence: 11 givenname: Zulita surname: Adriana Prieto fullname: Adriana Prieto, Zulita organization: Universidad Nacional de Trujillo, Trujillo, Perú |
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Subtitle | Avaliação preliminar da segurança do n-butanol do processo de extração de colágeno e do extrato de colágeno da pele de Oreochromis niloticus (tilápia) para uso dermocosmético |
Title | Preliminary safety evaluation of n-butanol from the collagen extraction process and of collagen extract from Oreochromis niloticus (tilapia) skin oriented for dermocosmetics |
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