Evaluation of aortic changes in elderly people autopsied with acquired immunodeficiency syndrome Aortic changes in elderly people with AIDS
Abstract Background To verify the distribution of the degree of fat deposits and percentage of collagen and elastic fibers in the intimal and medial layers of the aorta of elderly patients autopsied, with and without Acquired Immunodeficiency Syndrome (AIDS). Methods Twenty-six fragments of the aort...
Saved in:
Published in | Surgical and experimental pathology Vol. 1; no. 1 |
---|---|
Main Authors | , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
20.11.2018
|
Online Access | Get full text |
Cover
Loading…
Abstract | Abstract
Background
To verify the distribution of the degree of fat deposits and percentage of collagen and elastic fibers in the intimal and medial layers of the aorta of elderly patients autopsied, with and without Acquired Immunodeficiency Syndrome (AIDS).
Methods
Twenty-six fragments of the aorta from elderly patients autopsied in the period from 1982 to 2014, were collected and, divided into two groups, being 13 with AIDS and 13 without AIDS. The intensity of the atherosclerosis was macroscopically evaluated in a semi-quantitative way. To quantify the elastic and collagen fibers, it was used the Leica Qwin Plus® software.
Results
In the comparison of the macroscopic intensity of atherosclerosis, the AIDS group (
t
= 0.6969,
p
= 0.4992). Regarding elastic fibers, there was a significant increase in the AIDS group (U = 115,800;
p
< 0.0001). Comparing the groups, there was a significant increase of the collagen fibers in the aortic layers in the AIDS group (U = 114,100;
p
< 0.0001).
Conclusion
The infection by the HIV influence in the amount of fibers in the extracellular matrix and the intensity of lipid deposit, demonstrating that it may be a risk factor to be considered for the development of atherosclerosis. |
---|---|
AbstractList | Abstract
Background
To verify the distribution of the degree of fat deposits and percentage of collagen and elastic fibers in the intimal and medial layers of the aorta of elderly patients autopsied, with and without Acquired Immunodeficiency Syndrome (AIDS).
Methods
Twenty-six fragments of the aorta from elderly patients autopsied in the period from 1982 to 2014, were collected and, divided into two groups, being 13 with AIDS and 13 without AIDS. The intensity of the atherosclerosis was macroscopically evaluated in a semi-quantitative way. To quantify the elastic and collagen fibers, it was used the Leica Qwin Plus® software.
Results
In the comparison of the macroscopic intensity of atherosclerosis, the AIDS group (
t
= 0.6969,
p
= 0.4992). Regarding elastic fibers, there was a significant increase in the AIDS group (U = 115,800;
p
< 0.0001). Comparing the groups, there was a significant increase of the collagen fibers in the aortic layers in the AIDS group (U = 114,100;
p
< 0.0001).
Conclusion
The infection by the HIV influence in the amount of fibers in the extracellular matrix and the intensity of lipid deposit, demonstrating that it may be a risk factor to be considered for the development of atherosclerosis. |
ArticleNumber | 7 |
Author | da Silva, Aline Cristina Souza Espindula, Ana Paula Cavellani, Camila Lourencini Juliano, Gabriela Ribeiro Oliveira, Mariana Silva de Aquino Favarato, Grace Kelly Naves Aguiar, Laura Sanches da Silveira, Luciano Alves Matias Oliveira, Lívia Ferreira de Paula Antunes Teixeira, Vicente Torquato, Bianca Gonçalves Silva Ramalho, Luciana Santos Juliano, Guilherme Ribeiro da Fonseca Ferraz, Mara Lúcia |
Author_xml | – sequence: 1 givenname: Mariana Silva surname: Oliveira fullname: Oliveira, Mariana Silva – sequence: 2 givenname: Bianca Gonçalves Silva surname: Torquato fullname: Torquato, Bianca Gonçalves Silva – sequence: 3 givenname: Luciano Alves Matias orcidid: 0000-0001-5344-8667 surname: da Silveira fullname: da Silveira, Luciano Alves Matias – sequence: 4 givenname: Gabriela Ribeiro surname: Juliano fullname: Juliano, Gabriela Ribeiro – sequence: 5 givenname: Laura Sanches surname: Aguiar fullname: Aguiar, Laura Sanches – sequence: 6 givenname: Guilherme Ribeiro surname: Juliano fullname: Juliano, Guilherme Ribeiro – sequence: 7 givenname: Lívia Ferreira surname: Oliveira fullname: Oliveira, Lívia Ferreira – sequence: 8 givenname: Ana Paula surname: Espindula fullname: Espindula, Ana Paula – sequence: 9 givenname: Luciana Santos surname: Ramalho fullname: Ramalho, Luciana Santos – sequence: 10 givenname: Camila Lourencini surname: Cavellani fullname: Cavellani, Camila Lourencini – sequence: 11 givenname: Aline Cristina Souza surname: da Silva fullname: da Silva, Aline Cristina Souza – sequence: 12 givenname: Grace Kelly Naves surname: de Aquino Favarato fullname: de Aquino Favarato, Grace Kelly Naves – sequence: 13 givenname: Vicente surname: de Paula Antunes Teixeira fullname: de Paula Antunes Teixeira, Vicente – sequence: 14 givenname: Mara Lúcia surname: da Fonseca Ferraz fullname: da Fonseca Ferraz, Mara Lúcia |
BookMark | eNqdz0FOwzAQBVALtRKF9gDs5gIGOzhtWKMiDsDeWM6EDnI8wZOAcntSwYI1q_kj_b94V2qVOaNSN9bcWtvs78RVxh20sY02pqq1u1Cbqq6MblztVn_ypdqJvJuldNg_OFdv1OvxM6QpjMQZuIPAZaQI8RTyGwpQBkwtljTDgDwkhDCNPAhhC180niDEj4nK8lHfT5lb7CgS5jiDzLkt3ONWrbuQBHe_91rZp-PL47OOhUUKdn4o1Icye2v8WeN_NH7R-LPGu_v_bL4B3ABWGw |
Cites_doi | 10.1016/j.atherosclerosis.2008.08.039 10.1590/S0074-02761996000300023 10.1136/hrt.2008.161463 10.1590/S0066-782X2009001100019 10.1590/S0004-282X2004000500020 10.1590/S0103-11042013000200011 10.5935/abc.2013S010 10.1016/j.amjmed.2008.10.013 10.1590/S0066-782X2007001500004 10.1248/jhs.57.449 10.1097/01.aids.0000194801.51422.03 10.1189/jlb.0809580 10.1186/s12981-015-0061-z 10.6061/clinics/2012(09)15 10.1016/j.anndiagpath.2016.07.004 10.1016/j.medmal.2006.11.013 10.1046/j.0022-202x.2001.01544.x 10.1016/j.ypmed.2012.01.003 10.1253/circj.CJ-15-0167 10.1016/j.bjid.2012.11.007 10.1097/QAD.0b013e3283324283 10.1016/j.atherosclerosis.2005.01.024 10.1086/510852 10.1038/362801a0 10.1093/eurheartj/ehs092 |
ContentType | Journal Article |
DBID | AAYXX CITATION |
DOI | 10.1186/s42047-018-0025-4 |
DatabaseName | CrossRef |
DatabaseTitle | CrossRef |
DatabaseTitleList | CrossRef |
DeliveryMethod | fulltext_linktorsrc |
EISSN | 2520-8454 |
ExternalDocumentID | 10_1186_s42047_018_0025_4 |
GroupedDBID | 0R~ 7X7 8FI 8FJ AAFWJ AAYXX ABUWG ADBBV AFKRA AFPKN ALIPV ALMA_UNASSIGNED_HOLDINGS BCNDV BENPR BFQNJ BMC C24 C6C CCPQU CITATION EBS FYUFA GROUPED_DOAJ HMCUK IAO ITC M~E OK1 PIMPY RBZ RSV SOJ UKHRP |
ID | FETCH-crossref_primary_10_1186_s42047_018_0025_43 |
ISSN | 2520-8454 |
IngestDate | Thu Sep 26 18:48:42 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 1 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-crossref_primary_10_1186_s42047_018_0025_43 |
ORCID | 0000-0001-5344-8667 |
ParticipantIDs | crossref_primary_10_1186_s42047_018_0025_4 |
PublicationCentury | 2000 |
PublicationDate | 2018-11-20 |
PublicationDateYYYYMMDD | 2018-11-20 |
PublicationDate_xml | – month: 11 year: 2018 text: 2018-11-20 day: 20 |
PublicationDecade | 2010 |
PublicationTitle | Surgical and experimental pathology |
PublicationYear | 2018 |
References | Center For Disease Control (CDC) [homepage on the Internet] (25_CR3) 2002; 8 HT Xavier (25_CR30) 2013; 101 JD Estes (25_CR8) 2007; 195 A Kurtz (25_CR18) 2012; 54 DF Ketelhuth (25_CR15) 2015; 79 TW Shacker (25_CR27) 2005; 19 JR Insull (25_CR14) 2009; 122 JE Ho (25_CR13) 2009; 95 SM Crowe (25_CR6) 2010; 87 CM Verolet (25_CR28) 2015; 12 25_CR2 YV Bobryshev (25_CR1) 2005; 180 SA De Lima Pereira (25_CR7) 2007; 27 SL Pires (25_CR23) 2004; 62 M Ray (25_CR24) 2010; 24 DD Paiva (25_CR21) 1996; 91 JH Chung (25_CR5) 2001; 117 H Leng SX Yang (25_CR19) 2004; 16 25_CR20 A Serra (25_CR26) 2013; 97 GK Hansson (25_CR12) 2009; 202 A Frugoli (25_CR11) 2011; 15 J Perk (25_CR22) 2012; 33 R Ross (25_CR25) 1993; 362 W Chan (25_CR4) 2009; 14 H Wachi (25_CR29) 2011; 57 GKNA Favarato (25_CR9) 2016; 24 MP Krause (25_CR17) 2007; 89 MLF Ferraz (25_CR10) 2012; 67 AS Kramer (25_CR16) 2009; 93 |
References_xml | – volume: 202 start-page: 2 year: 2009 ident: 25_CR12 publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2008.08.039 contributor: fullname: GK Hansson – volume: 91 start-page: 371 issue: 3 year: 1996 ident: 25_CR21 publication-title: Mem Inst Oswaldo Cruz doi: 10.1590/S0074-02761996000300023 contributor: fullname: DD Paiva – volume: 95 start-page: 1193 year: 2009 ident: 25_CR13 publication-title: Heart doi: 10.1136/hrt.2008.161463 contributor: fullname: JE Ho – volume: 93 start-page: 561 year: 2009 ident: 25_CR16 publication-title: Arq Bras Cardiol doi: 10.1590/S0066-782X2009001100019 contributor: fullname: AS Kramer – volume: 62 start-page: 844 year: 2004 ident: 25_CR23 publication-title: Arq Neuropsiquiatr doi: 10.1590/S0004-282X2004000500020 contributor: fullname: SL Pires – volume: 15 start-page: 83 year: 2011 ident: 25_CR11 publication-title: Arq Cienc Saúde contributor: fullname: A Frugoli – volume: 97 start-page: 294 year: 2013 ident: 25_CR26 publication-title: Saúde em debate doi: 10.1590/S0103-11042013000200011 contributor: fullname: A Serra – volume: 101 start-page: 1 year: 2013 ident: 25_CR30 publication-title: Arq Bras Cardiol doi: 10.5935/abc.2013S010 contributor: fullname: HT Xavier – ident: 25_CR20 – volume: 122 start-page: s3 year: 2009 ident: 25_CR14 publication-title: Am J Med doi: 10.1016/j.amjmed.2008.10.013 contributor: fullname: JR Insull – volume: 89 start-page: 147 year: 2007 ident: 25_CR17 publication-title: Arq Bras Cardiol doi: 10.1590/S0066-782X2007001500004 contributor: fullname: MP Krause – volume: 57 start-page: 449 year: 2011 ident: 25_CR29 publication-title: J Health Sci doi: 10.1248/jhs.57.449 contributor: fullname: H Wachi – volume: 19 start-page: 2169 issue: 18 year: 2005 ident: 25_CR27 publication-title: AIDS doi: 10.1097/01.aids.0000194801.51422.03 contributor: fullname: TW Shacker – volume: 87 start-page: 589 year: 2010 ident: 25_CR6 publication-title: J Leukoc Biol doi: 10.1189/jlb.0809580 contributor: fullname: SM Crowe – volume: 12 start-page: 21 year: 2015 ident: 25_CR28 publication-title: AIDS Res Ther doi: 10.1186/s12981-015-0061-z contributor: fullname: CM Verolet – volume: 67 start-page: 1071 year: 2012 ident: 25_CR10 publication-title: Clinics doi: 10.6061/clinics/2012(09)15 contributor: fullname: MLF Ferraz – volume: 8 start-page: 1 year: 2002 ident: 25_CR3 publication-title: HIV Surveillance Rep contributor: fullname: Center For Disease Control (CDC) [homepage on the Internet] – volume: 24 start-page: 35 year: 2016 ident: 25_CR9 publication-title: Ann Diagn Pathol doi: 10.1016/j.anndiagpath.2016.07.004 contributor: fullname: GKNA Favarato – volume: 27 start-page: 229 issue: 4 year: 2007 ident: 25_CR7 publication-title: Med Mal Infect doi: 10.1016/j.medmal.2006.11.013 contributor: fullname: SA De Lima Pereira – volume: 14 start-page: 61 year: 2009 ident: 25_CR4 publication-title: J HIV Ther contributor: fullname: W Chan – volume: 117 start-page: 1218 issue: 5 year: 2001 ident: 25_CR5 publication-title: J Invest Dermatol doi: 10.1046/j.0022-202x.2001.01544.x contributor: fullname: JH Chung – volume: 54 start-page: s50 year: 2012 ident: 25_CR18 publication-title: Prev Med doi: 10.1016/j.ypmed.2012.01.003 contributor: fullname: A Kurtz – volume: 79 start-page: 924 year: 2015 ident: 25_CR15 publication-title: Circ J doi: 10.1253/circj.CJ-15-0167 contributor: fullname: DF Ketelhuth – volume: 16 start-page: 249 issue: 3 year: 2004 ident: 25_CR19 publication-title: Exp Gerontol contributor: fullname: H Leng SX Yang – ident: 25_CR2 doi: 10.1016/j.bjid.2012.11.007 – volume: 24 start-page: 123 year: 2010 ident: 25_CR24 publication-title: AIDS doi: 10.1097/QAD.0b013e3283324283 contributor: fullname: M Ray – volume: 180 start-page: 293 issue: 2 year: 2005 ident: 25_CR1 publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2005.01.024 contributor: fullname: YV Bobryshev – volume: 195 start-page: 551 issue: 4 year: 2007 ident: 25_CR8 publication-title: J Infect Dis doi: 10.1086/510852 contributor: fullname: JD Estes – volume: 362 start-page: 801 year: 1993 ident: 25_CR25 publication-title: Nature doi: 10.1038/362801a0 contributor: fullname: R Ross – volume: 33 start-page: 1635 year: 2012 ident: 25_CR22 publication-title: Eur Heart J doi: 10.1093/eurheartj/ehs092 contributor: fullname: J Perk |
SSID | ssj0002769445 |
Score | 4.2091985 |
Snippet | Abstract
Background
To verify the distribution of the degree of fat deposits and percentage of collagen and elastic fibers in the intimal and medial layers of... |
SourceID | crossref |
SourceType | Aggregation Database |
Subtitle | Aortic changes in elderly people with AIDS |
Title | Evaluation of aortic changes in elderly people autopsied with acquired immunodeficiency syndrome |
Volume | 1 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1JT8JAFJ4gXrwYjRpXMgdPNkUp0-0oBiHGLYIJtzrTTk0TQhGpB_-cf833phsgJuilaSfT14H3Zd4ybyHk1OauEYZBoPtuU-gMZIDuBq6vOxZYPYHPmS3RULy7t7rP7GZgDiqVr5mopWQq6v7n0ryS_3AVxoCvmCX7B84WRGEA7oG_cAUOw3UlHreLUt3qOD_GGVkqrwpzldiCG90XKkxc48k0Hr9HecA59zEKGJ4izBGJA4nFJFQm5rIyBr1k8lpUFpjrC4BNjeec8w9D2EIj1cAIc4EAgFzrRcOPQgL048kbrFt5aVvKq6J1QAXFM3ubD7EO7tz0IH09J3mboCcm1i7VzDv4_byMg0zQbaMId7iYRHLItadIwKvxrH-j4WCin3FRboOGCQauw9JS03W5ZCzfxxfh-lM6qMOqd2ZgeQr8lGrmy0pRmB__L0jIIm5RWUyO5aUkPCDhIQmPrZF1w3ZNs0rWW-37x6fCzWfYlstUq-xizdnZOtA5_7GUGe1oRs3pb5HNzD6hlynYtklFjnbISwk0Goc0BRrNgEajEc2ARlOg0QJoFIFGc6DRRaDRHGi7pHHd7l919XxZ3jitguL9-l8090h1FI_kPqGWc8FNEZqGEIz5DS5E0w9BDIBK5EjeEAfkbHW6h3-ZfEQ2SjAdk-p0ksgTUB-nopaxqKbcL98f13lG |
link.rule.ids | 315,786,790,870,27955,27956 |
linkProvider | ProQuest |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Evaluation+of+aortic+changes+in+elderly+people+autopsied+with+acquired+immunodeficiency+syndrome&rft.jtitle=Surgical+and+experimental+pathology&rft.au=Oliveira%2C+Mariana+Silva&rft.au=Torquato%2C+Bianca+Gon%C3%A7alves+Silva&rft.au=da+Silveira%2C+Luciano+Alves+Matias&rft.au=Juliano%2C+Gabriela+Ribeiro&rft.date=2018-11-20&rft.issn=2520-8454&rft.eissn=2520-8454&rft.volume=1&rft.issue=1&rft_id=info:doi/10.1186%2Fs42047-018-0025-4&rft.externalDBID=n%2Fa&rft.externalDocID=10_1186_s42047_018_0025_4 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2520-8454&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2520-8454&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2520-8454&client=summon |