Abstract 009: Age-related Clonal Hematopoiesis Predisposes To Hypertension In Mice Through An Inflammasome Mechanism

• Published in: Hypertension (Dallas, Tex. 1979) Vol. 80; no. Suppl_1
• Main Authors: Polizio, Ariel, Min, Kyung-Duk, Yura, Yoshimitsu, Marino, Lucila, Rolauer, Luca, Miura-Yura, Emiri, Evans, Megan A, Park, Eunbee, Good, Miranda, Wolpe, Abigail, Grandoch, Maria, Isakson, Brant, Walsh, Kenneth
• Format: Journal Article
• Language: English
• Published: 01.09.2023

Abstract only Hypertension incidence increases with age and represents one of the most prevalent risk factors for cardiovascular disease (CVD). Clonal events in the hematopoietic system resulting from somatic mutations in “driver” genes such as Tet2 are prevalent in elderly individuals in the absenc...