Abstract 119: Mitochondrial Redox Mechanisms Leading To Sustained Radiation-induced Endothelial Injury

• Published in: Arteriosclerosis, thrombosis, and vascular biology Vol. 41; no. Suppl_1
• Main Authors: Ait-Aissa, Karima, Koval, Olha, Lindsey, Nathanial R, Broadhurst, Kimberly, Grumbach, Isabella M
• Format: Journal Article
• Language: English
• Published: 01.09.2021

Abstract only Rationale: Radiation therapy strongly increases the risk of developing atherosclerotic vascular disease, such as coronary and carotid artery disease. Recently, we found that in vitro inhibition of the mitochondrial Ca 2+ uniporter (MCU) protects from endothelial barrier breakdown follo...