Abstract B01: Mutagenic and tumorigenic effects of follicular fluid in the context of p53 loss: Initiation of fimbria carcinogenesis

Ovulation is the strongest risk factor for ovarian high-grade serous carcinoma (HGSC) that largely originates from the fallopian tube fimbriae and always carries loss-of-function mutations of TP53 in both early and late lesions. Mature ovarian follicle contains high level of reactive oxygen species...

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Bibliographic Details
Published inClinical cancer research Vol. 22; no. 2_Supplement; p. B01
Main Authors Chu, Tang-Yuan, Huang, Hsuan-Shun, Hsu, Che-Fang
Format Journal Article
LanguageEnglish
Published 15.01.2016
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ISSN1078-0432
1557-3265
DOI10.1158/1557-3265.OVCA15-B01

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