Abstract B114: Effect of spatial and temporal inter-tumoral heterogeneity on homologous recombination deficiency scores in high grade serous ovarian cancer

• Published in: Cancer research (Chicago, Ill.) Vol. 84; no. 5_Supplement_2; p. B114
• Main Authors: Christie, Elizabeth L., Lorentzen, Marc, Liu, Maiqi, Burdett, Nikki, Curry, Edward, Kwok, Chun Hei, Pandey, Ahwan, Nixon, Katherine, Ploski, Jennifer, Clark, James J., McNeish, Iain, Bowtell, David D.L., Krell, Jonathan, Fotopoulou, Christina, Cunnea, Paula
• Format: Journal Article
• Language: English
• Published: 04.03.2024

Abstract High-grade serous ovarian cancer (HGSC) is the most common and lethal subtype of ovarian cancer. Extensive genomic instability and heterogeneity are characteristics of HGSC, with near-ubiquitous TP53 loss-of-function mutations, defects in homologous recombination (HR) repair, and extensive...