Abstract B003: The OTX2 gene induces tumor growth and triggers leptomeningeal metastasis by regulating the mTOR signaling pathway in medulloblastomas

Abstract Medulloblastoma (MB) is the most common malignant brain tumor in children, and is classified into four genetic subgroups: WNT, SHH, Group 3 and Group 4. These subgroups are driven by major canonical driver genes (CDG). The OTX2 (Orthodenticle homeobox 2) oncogene is overexpressed or amplifi...

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Bibliographic Details
Published inCancer research (Chicago, Ill.) Vol. 84; no. 5_Supplement_1; p. B003
Main Authors Mesias, Elisabet Ampudia, Cameron, Charles Scott, Anderson, Sarah, Abrahante Lloréns, Juan E., Moertel, Christopher L., Odde, David J., Saydam, Okay
Format Journal Article
LanguageEnglish
Published 04.03.2024
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