Abstract 4063: SAR445877, an anti-PD-1 antibody-IL-15 mutein fusion protein restores function to exhausted T cells

• Published in: Cancer research (Chicago, Ill.) Vol. 84; no. 6_Supplement; p. 4063
• Main Authors: Pratumchai, Isaraphorn, Bernardo, Marie, Marquardt, Kristi Lynn, Zhu, Chen, Menas, Fatima, Carrio, Roberto, Byers, Tony, Shaffer, Donald, Li, Xiangming, Teijaro, John Ross
• Format: Journal Article
• Language: English
• Published: 22.03.2024

Abstract During persistent viral infections and cancer, antigen-specific T cells become exhausted, express elevated levels of inhibitory receptors and gradually lose their functional potential. Immune checkpoint blockade can restore function of exhausted T cells to result in tumor clearance, however...