Abstract 3865: Multiple cancer types rapidly escape from multiple MAPK inhibitors to generate mutagenesis-prone subpopulations

• Published in: Cancer research (Chicago, Ill.) Vol. 83; no. 7_Supplement; p. 3865
• Main Authors: Hoffman, Timothy E., Yang, Chen, Nangia, Varuna, Ill, Christopher Ryland, Spencer, Sabrina L.
• Format: Journal Article
• Language: English
• Published: 04.04.2023

Abstract Many cancers harbor pro-proliferative mutations of the mitogen-activated protein kinase (MAPK) pathway and many targeted inhibitors now exist for clinical use, but drug resistance remains a major issue. We previously showed that BRAF-driven melanoma cells treated with BRAF inhibitors can no...