Abstract 330: EP300 loss drives tumorigenesis in bladder cancer via activation of IL-6/JAK/STAT3 signaling

• Published in: Cancer research (Chicago, Ill.) Vol. 83; no. 7_Supplement; p. 330
• Main Authors: Gao, Sizhi P., Rodrigues, James A., Sabel, Amanda R., Luo, Jiaqian, Ziyu, Chen, Tang, Xinran, Mascareno, Eduardo A., Rustgi, Naryan, Al-Ahmadie, Hikmat, Kim, Kwanghee, Pietzak, Eugene J., Iyer, Gopakumar V., Solit, David B.
• Format: Journal Article
• Language: English
• Published: 04.04.2023

Abstract Bladder cancer (BLCA) is the sixth most common cancer in the U.S with 83,730 new cases, accounting for 17,200 deaths in the year 2021 and 212,536 deaths worldwide. EP300, a histone acetyltransferase gene, is mutated in ~17% of BLCA and in other cancer types such as endometrial cancer. The m...