Abstract 964: Induction of immunogenic cell death and interferon signaling by carboplatin and the ATR inhibitor M6620 may contribute to anti-tumor activity of M6620-carboplatin-avelumab triplet combination in MC38 tumor model

• Published in: Cancer research (Chicago, Ill.) Vol. 80; no. 16_Supplement; p. 964
• Main Authors: Alimzhanov, Marat, George, Ashwin, Shah, Parantu, Zimmerman, Astrid, Schroeder, Andreas, Falk, Martin, Amendt, Christiane, Halle, Joern-Peter, Blaukat, Andree, Zenke, Frank, Soulard, Patricia
• Format: Journal Article
• Language: English
• Published: 15.08.2020

Abstract Ataxia-telangiectasia mutated and Rad3-related kinase (ATR) is one of the key players in the DNA damage response (DDR) to replication stress. M6620 is a potent and selective ATR inhibitor which has been shown to sensitize cancer cells to the lethal effects of DNA-damaging chemotherapeutic a...