Abstract 6604: Drug responsive domain regulation of IL15-engineered T cells provides pharmacological control over antigen-independent cell expansion

• Published in: Cancer research (Chicago, Ill.) Vol. 80; no. 16_Supplement; p. 6604
• Main Authors: Shamah, Steven, Elpek, Kutlu, Ezell, Tucker, Fleury, Michelle, Gallo, Michael, Gori, Jennifer, Heller, Scott, Inniss, Mara, Langley, Meghan, Olinger, Grace, Richardson, Celeste, Tran, Karen, Sethi, Dhruv, Sun, Dexue, Suri, Vipin
• Format: Journal Article
• Language: English
• Published: 15.08.2020

Abstract Engineered T cell therapies have been remarkably successful in the treatment of B cell malignancies, yet lack of control over these “living drugs” can lead to significant toxicities or limited efficacy. One particular challenge is the achievement of durable anti-tumor responses because the...