Abstract 527: Isolation of large and diverse monoclonal antibody panels against the multipass membrane protein targets Kv1.3, P2X7, and Claudin 18.2

• Published in: Cancer research (Chicago, Ill.) Vol. 80; no. 16_Supplement; p. 527
• Main Authors: Stafford, Lewis J., Willis, Sharon, Rucker, Joseph, Doranz, Benjamin, Chambers, Ross
• Format: Journal Article
• Language: English
• Published: 15.08.2020

Abstract Monoclonal antibodies (MAbs) are a well-established treatment approach in oncology and other diseases. Nevertheless, multipass membrane proteins are largely inaccessible as MAb targets due to their poor expression, membrane-dependent structure, small extracellular regions, and high sequence...