Abstract 3765: c-Kit mediated phosphorylation of Spred1 regulates Neurofibromin-Spred1 interaction

• Published in: Cancer research (Chicago, Ill.) Vol. 80; no. 16_Supplement; p. 3765
• Main Authors: Lorenzo, Claire, Young, Lucy C., Tannka, Alexandra, Urisman, Anatoly, McCormick, Frank
• Format: Journal Article
• Language: English
• Published: 15.08.2020

Abstract Spred1 negatively regulates Ras/MAPK signaling following growth factor stimulation. Spred1 inhibits Ras by binding and localizing Neurofibromin, a RasGAP, to the plasma membrane to accelerate Ras GTPase activity. c-Kit, a receptor tyrosine kinase (RTK), is known to interact with Spred1 but...