Abstract 3510: IDH1-R132H tumor cells are not robustly sensitive to PARP inhibition in a 2-HG dependent manner

• Published in: Cancer research (Chicago, Ill.) Vol. 79; no. 13_Supplement; p. 3510
• Main Authors: Aguado-Fraile, Elia, Hudson, Christine, Sleger, Taryn, Ronseaux, Sebastien, Narayanaswamy, Rohini, Choe, Sung, Wu, Bin, Kalev, Peter, Nicolay, Brandon
• Format: Journal Article
• Language: English
• Published: 01.07.2019

Abstract Mutations in the metabolic enzymes isocitrate dehydrogenase (IDH) 1 or 2 arise in a variety of malignancies and lead to the production of the oncometabolite (D)-2-hydroxyglutarate (2-HG). The recent approval by the FDA of mutant IDH1 and IDH2 (mIDH1/2) inhibitors in patients with mIDH1/2 re...