Abstract 2560: Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells

• Published in: Cancer research (Chicago, Ill.) Vol. 79; no. 13_Supplement; p. 2560
• Main Authors: Lieb, Simone, Blaha-Ostermann, Silvia, Kamper, Elisabeth, Ehrenhöfer-Wölfer, Katharina, Schlattl, Andreas, Wernitznig, Andreas, Lipp, Jesse, Nagasaka, Kota, Bader, Gerd, Neumueller, Ralph, Kraut, Norbert, Pearson, Mark, Woehrle, Simon, Petronczki, Mark
• Format: Journal Article
• Language: English
• Published: 01.07.2019

Targeted cancer therapy is based on exploiting selective dependencies of tumor cells. By leveraging recent large-scale genomic profiling and functional screening of cancer cell lines we identified Werner syndrome helicase (WRN) as a novel specific vulnerability of microsatellite instability-high (MS...