Abstract 2338: Checkpoint inhibitor-induced colitis shares mucosal histopathological features with inflammatory bowel and graft-versus-host disease

• Published in: Cancer research (Chicago, Ill.) Vol. 79; no. 13_Supplement; p. 2338
• Main Authors: Lopez, Sara Hone, Kats-Ugurlu, Gursah, Vries, Liesbeth De, Groot, Marco De, Visschedijk, Marijn, Jalving, Mathilde, Haan, Jacco de
• Format: Journal Article
• Language: English
• Published: 01.07.2019

Abstract Background: Checkpoint inhibitor-induced colitis (CIC) is a severe side-effect of immune-checkpoint inhibitors (ICI). Its pathophysiology is poorly understood, impairing improvement of prevention and treatment strategies. CD4+ and CD8+ T cells and CD68+ macrophages are thought to be critica...