Abstract 965: Deleterious effects of MAPK pathway hyperactivation in BRAF-mutant melanoma

• Published in: Cancer research (Chicago, Ill.) Vol. 78; no. 13_Supplement; p. 965
• Main Authors: Leung, Grace P., Feng, Tianshu, Shirley, Matthew D., Sigoillot, Frederic D., Ruddy, David A., Freeman, Alyson K., Jaskelioff, Mariela, Stuart, Darrin D.
• Format: Journal Article
• Language: English
• Published: 01.07.2018

Abstract The most frequent genetic alterations in melanoma are gain-of-function mutations in BRAF, which result in addiction to RAF-MEK-ERK signaling. Given the centrality of this pathway in many cancers, inhibitors have been developed against various nodes in this signaling axis. Despite the succes...