Abstract 5573: A high-affinity Optide (optimized peptide) inhibitor of the Hippo pathway’s YAP-TEAD interaction

• Published in: Cancer research (Chicago, Ill.) Vol. 77; no. 13_Supplement; p. 5573
• Main Authors: Crook, Zachary R., Bradley, Philip, Sevilla, Gregory, Friend, Della, King, Chris, Mhyre, Andrew, Strong, Roland, Baker, David, Olson, James M.
• Format: Journal Article
• Language: English
• Published: 01.07.2017

Abstract The HIPPO pathway plays a critical role in contact inhibition, a pathway that is commonly dysregulated in many human cancers (including liver, colon, ovarian, and lung). The signaling pathway culminates in the intranuclear interaction of the transcriptional co-activator YAP and the transcri...