Abstract 797: A splicing variant of TERT identified by GWAS interacts with menopausal estrogen therapy in risk of ovarian cancer

• Published in: Cancer research (Chicago, Ill.) Vol. 76; no. 14_Supplement; p. 797
• Main Authors: Lee, Alice W., Bomkamp, Ashley, Bandera, Elisa V., Jensen, Allan, Ramus, Susan J., Goodman, Marc T., Rossing, Mary Anne, Modugno, Francesmary, Moysich, Kirsten B., Chang-Claude, Jenny, Rudolph, Anja, Gentry-Maharaj, Aleksandra, Terry, Kathryn L., Gayther, Simon A., Cramer, Daniel W., Doherty, Jennfier A., Schildkraut, Joellen M., Kjaer, Susanne K., Ness, Roberta B., Menon, Usha, Berchuck, Andrew, Mukherjee, Bhramar, Roman, Lynda, Pharoah, Paul D., Chenevix-Trench, Georgia, Wu, Anna H., Pike, Malcolm C., Pearce, Celeste L.
• Format: Journal Article
• Language: English
• Published: 15.07.2016

Abstract Menopausal estrogen-alone therapy (ET) is a well-established risk factor for serous and endometrioid ovarian carcinoma. Genetics also plays an important role in ovarian carcinoma etiology, which is partly attributable to 18 confirmed susceptibility loci identified by genome-wide association...